MGH CTNI POC Trial Designs
The staff at the MGH CTNI have extensive experience in designing POC protocols across all CNS areas, including major depressive disorder, treatment resistant depression (TRD), post-traumatic stress disorder, schizophrenia, bipolar disorder and women’s mental health.
Our protocols utilize methodological approaches that enhance signal detection and reduce sample size requirements by utilizing the following:
- innovative designs to reduce placebo effect
- novel outcome measures designed to enhance signal detection
- highly sensitive assessments of side effect profiles
- peripheral and neuroimaging biomarkers.