Protocol Design

The staff at the MGH CTNI staff have designed protocols for over 100 trials.  Our areas of expertise include the design of protocols for studies in all CNS areas, including major depressive disorder, treatment resistant depression (TRD), post-traumatic stress disorder, schizophrenia, bipolar disorder and women’s mental health.  Our protocols utilize the following: a) innovative designs to reduce placebo effect; b) novel outcome measures designed to enhance signal detection; c) highly sensitive assessments of side effect profiles; d) peripheral and neuroimaging biomarkers.