POC Trial Designs

The staff at the MGH CTNI have extensive experience in designing POC protocols across all CNS areas, including major depressive disorder, treatment resistant depression (TRD), post-traumatic stress disorder, schizophrenia, bipolar disorder and women’s mental health.  Our protocols utilize methodological approaches that enhance signal detection and reduce sample size requirements by utilizing the following: a) innovative designs to reduce placebo effect; b) novel outcome measures designed to enhance signal detection; c) highly sensitive assessments of side effect profiles; d) peripheral and neuroimaging biomarkers.